JAK/STAT3 Signaling Pathway and Its Inhibitors in Tumor Therapy / 中国药学杂志

Signal transducers and activators of transcription 3 generally located in cytoplasm is a key intra-cellular transcription. So far, STAT3 has been known that could be activated by several different upstream kinase within cell, the most common one of which is Janus kinase. The aberrant activation of STAT3 induces tumorigenesis and promotes tumor development. Consequently, researchers have always been committed to developing novel anti-tumor drugs targeting JAK/STAT3 pathway signaling. In this review, researches as well as clinical trials of JAK/STAT3 inhibitors published over the past several years are collected and the targets, mechanism and pharmacological properties of certain inhibitors are summarized.